@u1160_Equipe1 proud to announce the publication of our latest
paper on Sec22b and plasma cells in PNAS!
https://www.pnas.org/doi/10.1073/pnas.2213056120
Here is a lay summary of what is it about and why it is important
https://www.growkudos.com/publications/10.1073%25252Fpnas.2213056120/reader
Sec22b: A new regulator of antibody-secreting cellfunction and survival
www.growkudos.com
Plasma cells aremini-factories responsible for antibody production and secretion. These cellsare generated after each infection or vaccination and can persist for longperiods of time in our body. The antibodies they produce are essential toprotect us from infection. However, in some circumstances plasma cells andantibodies may be detrimental for our health. This is the case for example insome autoimmune diseases like systemic lupus erythematosus in which plasmacells produce pathologic antibodies. In this study, we demonstrated that theprotein Sec22b is a critical regulator of antibodysecretion but also of plasma cell survival. In absence of Sec22b, theantibody-mediated vaccinal and anti-viral responses were totally abrogated. Atthe mechanistic level, we showed that Sec22b regulates the expansion and shapeof an intracellular organelle called the endoplasmic reticulum responsible forprotein production and transport. Moreover, Sec22b isimportant for the function of mit
@u1160_Equipe1 Retrouvezici notre dernière revue sur la signalisation de CXCR4, un rhéostat de laréponse humorale
https://www.medecinesciences.org/en/articles/medsci/full_html/2023/01/msc220204/msc220204.html
médecine/sciences (M/S), revue internationale dans le domaine de la recherche biologique, médicale et en santé
@u1160_Equipe1 check out our latest review onthe cellular biology of plasma cells.
https://www.sciencedirect.com/science/article/pii/S0165247823000056
@u1160_Equipe1 Welcome to Houda and Inès that are starting their M2 inthe lab!
